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Zamora's friend and roommate during the show, Judd Winick, went on to become a successful comic book writer, and wrote the Eisner Award-nominated graphic novel Pedro and Me, about his friendship with Zamora, as well as high-profile Los Angeles cast member Beth Stolarczyk has produced men's and women's calendars and television programs featuring reality TV personalities, including herself and other Real World alumni, including Tami Roman (who became cast member on Basketball Wives and spinoff Basketball Wives LA), 2002–2003 Las Vegas' Trishelle Cannatella, 2002 Chicago's Tonya Cooley and Back to New York's Coral Smith.
London cast member Jacinda Barrett's acting career includes films such as Ladder 49, The Namesake, The Human Stain, and Bridget Jones: The Edge of Reason.
Tracy Grandstaff, one of the original seven picked for what has come to be known as "Season 0", went on to minor fame as the voice of the animated Beavis and Butt-Head character Daria Morgendorffer, who eventually got her own spinoff, Daria.
Dutch TV producer Erik Latour claims that the ideas for The Real World were directly derived from his television show Nummer 28, which aired in 1991 on Dutch television.
The show also gained widespread attention with its third season, The Real World: San Francisco, which aired in 1994, and depicted the conflict between David "Puck" Rainey, a bicycle messenger criticized for his poor personal hygiene, As the show increased in popularity, Zamora's life as someone living with AIDS gained considerable notice, garnering widespread media attention.
Zamora was one of the first openly gay men with AIDS to be portrayed in popular media, and after his death on November 11, 1994 (mere hours after the final episode of his season aired), he was lauded by then-President Bill Clinton.