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Filter-it™ is a program for filtering out molecules with unwanted properties.

The traditional approach requires focusing on diseases that are typically chronic and multifactorial, while relying on multilayered investment and requiring large-scale clinical trials.

Ultimately, it’s a model that’s become too cumbersome and costly to maintain.

Bringing together data from multiple pharmaceutical companies, these investigations have revealed some interesting findings.

A recent study by Waring and colleagues analyzed the main causes of attrition in drug development based on a review of 812 NCEs under development by Astra Zeneca, Eli Lilly, Glaxo Smith Kline and Pfizer.

These findings highlight the urgent need to improve overall health of the pharmaceutical pipeline.

But while the pressure to innovate is greater than ever before, the FDA is actually approving 25% fewer drugs than it did in the 1990s. Why are pharmaceutical companies spending more money and time (often up to 15 years) developing new chemical entities (NCEs), only to see them fail before reaching the market? Several studies have sought to understand the key causes of attrition in drug discovery and development.

However, their widespread adoption across large sections of the industry has led some to question whether they are in fact contributing to the challenge of attrition.

While there’s certainly a case for adopting a more nuanced and pragmatic approach to applying Lipinski’s rules, the Waring study shows that the principles underpinning them still shape success.

While many drivers of attrition were identified, non-clinical toxicity, and interestingly, portfolio rationalization were cited as the most common causes of failure in drug development.

When it comes to the clinical stage, clinical safety and efficacy were the most common contributing factors to program failure, accounting for just under two-thirds of overall attrition.

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