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Gradual tapering of the dose should be considered when discontinuing olanzapine.Special populations Elderly patients A lower starting dose (5mg/day) is not routinely indicated but should be considered for those 65 and over when clinical factors warrant (see section 4.4).Age The use of olanzapine in the treatment of dopamine agonist associated psychosis in patients with Parkinson's disease is not recommended.In clinical trials, worsening of Parkinsonian symptomatology and hallucinations were reported very commonly and more frequently than with placebo (see section 4.8), and olanzapine was not more effective than placebo in the treatment of psychotic symptoms.If a new manic, mixed, or depressive episode occurs, Olanzapine Accord treatment should be continued (with dose optimization as needed), with supplementary therapy to treat mood symptoms, as clinically indicated.During treatment for schizophrenia, manic episode, and recurrence prevention in bipolar disorder, daily dosage may subsequently be adjusted on the basis of individual clinical status within the range 5-20mg/day.Smokers The starting dose and dose range need not be routinely altered for non- smokers relative to smokers.

For patients who have been receiving Olanzapine Accord for treatment of manic episode, continue therapy for preventing recurrence at the same dose.Dose escalation, when indicated, should be conservative in such patients. Paediatric population Olanzapine is not recommended for use in children and adolescents below 18 years of age due to a lack of data on safety and efficacy.A greater magnitude of weight gain, lipid and prolactin alterations has been reported in short-term studies of adolescent patients than in studies of adult patients (see sections 4.4, 4.8, 5.1 and 5.2).Olanzapine Accord is indicated for the treatment of schizophrenia.Olanzapine Accord is effective in maintaining the clinical improvement during continuation therapy in patients who have shown an initial treatment response.

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